產品屬性：
產品名稱 | Benzonatate |
規格 | 1mg、5mg、10mg |
貨號 | EY-01Y9588 |
Cas No.: 104-31-4
別名: N/A
化學名: 4-(butylamino)-benzoic acid, 3,6,9,12,15,18,21,24,27-nonaoxaoctacos-1-yl ester
分子式: C30H53NO11
分子量: 603.8
溶解度: 50mg/mL in DMSO, or in DMF
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Benzonatate is a reversible voltage-gated sodium channel blocker.[1] It blocks Nav1.7 currents in a concentration- and voltage-dependent manner (IC50s = 5.9 and 1.4 μM at holding potentials of -100 and -70 mV, respectively) and inhibits action potential firing in catecholamine A differentiated (CAD) cells. Benzonatate also blocks 80% of Nav1.3 currents in N1E-115 cells when used at a concentration of 100 μM. In vivo, benzonatate (0.85 mg/min) reduces the frequency, but has no effect on the amplitude, of the cough reflex in anesthetized dogs.[2] Formulations containing benzonatate have been used as antitussive agents for the treatment of coughs.
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