產品屬性：
產品名稱 | CALP1 (trifluoroacetate salt) |
規格 | 1mg、5mg |
貨號 | EY-01Y9557 |
Cas No.: N/A
別名: N/A
化學名: N/A
分子式: C40H75N9O10?XCF3COOH
分子量: 842.1
溶解度: DMF: 5 mg/ml,DMSO: 5 mg/ml,Ethanol: 0.5 mg/ml,PBS (pH 7.2): 0.5 mg/ml
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
CALP1 is an 8-residue calcium-like peptide that interacts with an EF hand motif based on the troponin C superfamily calcium binding site. It binds to calmodulin (Kd = 88 μM) and activates phosphodiesterase in the presence of calmodulin and absence of calcium. CALP1 also acts as a cell-permeable inhibitor of calcium influx through glutamate receptor channels in cultured rat neocortical neurons thereby inhibiting excitatory cytotoxicity (IC50 = 52.48 μM) and apoptosis (IC50 = 44.78 μM). CALP1 (1 mg/kg) pretreatment prevents increases in lung alveolar inflammatory cells after six, but not 24, hours in sensitized guinea pigs challenged with ovalbumin in a model of allergic asthma. It also decreases radical production induced by phorbol 12-myristate 13-acetate in broncho-alveolar lavage cells after six and 24 hours and dose-dependently decreases histamine-induced hyperresponsiveness in isolated guinea pig tracheal rings.
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