產品屬性：
產品名稱 | CAY10561 |
規格 | 500μg、1mg、5mg、10mg |
貨號 | EY-01Y9602 |
Cas No.: 933786-58-4
別名: N/A
化學名: N/A
分子式: C22H17Cl2FN4O2
分子量: 459.3
溶解度: DMF: 2.5 mg/ml,DMSO: 1.5 mg/ml,Ethanol: 5 mg/ml,Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
The extracellular signal-regulated kinase (ERK) signal transduction pathway regulates a diverse array of cellular processes. These processes include cell survival, proliferation, motility, and differentiation and are constitutively activated in cancers involving lung, colon, pancreas, kidney, and ovary. CAY10561 is a potent, ATP-competitive inhibitor of ERK2 (Ki = 2 nM). This compound is highly selective for ERK2 compared to other kinases such as PKA (Ki = 0.39 μM) and JNK3 (Ki = 4 μM). CAY10561 inhibits proliferation of COLO 205 cells with an IC50 value of 0.54 μM.
特別提醒公司產品僅供科研使用
