產品屬性：
產品名稱 | AT-130 |
規格 | 5 mg、10 mg、25 mg、50 mg、100 mg |
貨號 | EY-01Y9653 |
Cas No.: 211364-06-6
別名: N/A
化學名: N/A
分子式: C22H22BrN3O5
分子量: 488.33
溶解度: DMSO : 25 mg/mL (51.19 mM)
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
AT-130, a phenylpropenamide derivative, is a potent hepatitis B virus (HBV) replication non-nucleoside inhibitor. AT-130 inhibits the viral DNA synthesis with an IC50 of 0.13 uM. AT-130 inhibits both wt and mutant HBVs. AT-130 has anti-HBV activity in hepatoma cells[1][2][3].AT-130 inhibits Wt HBV (IC50=2.4 μM), rtL180M HBV (IC50=9.8 μM), rtM204I HBV (IC50=35.6 μM)[1]. AT-130 (0.1, 1, 5, 10, 100 uM; for 7 days) causes dose-dependent inhibition of wt HBV replication in HepG2 cells transduced with HBV baculovirus. AT-130 at a concentration of 2.5 uM, reduces encapsidated HBV DNA by 50% (IC50) and at 18.5 uM by 90% (IC90)[1]. AT-130 has no toxic to either HepG2 or Huh-7 cells at concentrations of up to 250 μM[1]. AT-130 (0.005, 0.05, 0.5, 5, 50 uM) does not inhibit HBV DNA synthesis by blocking the HBV endogenous DNA polymerase reaction directly in Huh 7 or HepG2 cells. AT-130 inhibits HBV DNA replication in hepatoma cells but has no effect on viral DNA polymerase activity or core protein translation[3]. AT-130 (2.5, 18.5 uM) has no effect on total HBV RNA production but does reduce encapsidated RNA. AT-130 does not affect core protein or nucleocapsid production and the activity of the protein expression vector[3].
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