產品屬性：
產品名稱 | Carbinoxamine-d6 (maleate) |
規格 | 1 mg、5 mg |
貨號 | EY-01Y10460 |
Cas No.: N/A
別名: N/A
化學名: N/A
分子式: C16H13ClD6N2O·C4H4O4
分子量: 412.9
溶解度: Acetonitrile: soluble,DMSO: soluble
儲存條件: -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Carbinoxamine-d6 is intended for use as an internal standard for the quantification of carbinoxamine by GC- or LC-MS. Carbinoxamine is a competitive histamine H1 receptor antagonist (Ki = 2.3 nM) and first generation antihistamine.1 It is also an L-type calcium channel inhibitor (Ki = 1.08 nM).2 Carbinoxamine decreases negative inotropic activity in isolated guinea pig left atria and negative chronotropic activity in guinea pig spontaneously beating isolated right atria (EC50s = 250 and 480 nM, respectively). Formulations containing carbinoxamine have been used in the treatment of allergic rhinitis.1.Tran, V.T., Chang, R.S.L., and Snyder, S.H.Histamine H1 receptors identified in mammalian brain membranes with [3H]mepyramineProc. Natl. Acad. Sci. U.S.A.75(12)6290-6294(1978)
2.Carosati, E., Budriesi, R., Ioan, P., et al.Discovery of novel and cardioselective diltiazem-like calcium channel blockers via virtual screeningJ. Med. Chem.51(18)5552-5565(2008)
特別提醒公司產品僅供科研使用
