產品屬性：
產品名稱 | CU-115 |
規格 | 1 mg、5 mg、10 mg |
貨號 | EY-01Y10434 |
Cas No.: 2471982-20-2
別名: N/A
化學名: N/A
分子式: C21H11F7INO2
分子量: 569.2
溶解度: DMF: 10mg/mL,DMSO: 10mg/mL,DMSO:PBS (pH 7.2) (1:5): 0.15mg/mL,Ethanol: 0.25mg/mL
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
CU-115 is a toll-like receptor 8 (TLR8) antagonist (IC50 = 1.04 μM).1 It is selective for TLR8 over TLR7 (IC50 = >50 μM). CU-115 inhibits increases in type I IFN transcriptional activity induced by the ssRNA nucleic acid ligands 3p-hpRNA or G3-YSD in a luciferase reporter assay when used at concentrations of 5 and 20 μM. It decreases TNF-α and IL-1β production induced by R-848 in THP-1 cells when used at a concentration of 5 μM. 1.Padilla-Salinas, R., Anderson, R., Sakaniwa, K., et al.Discovery of novel small molecule dual inhibitors targeting toll-like receptors 7 and 8J. Med. Chem.62(22)10221-10244(2019)
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