產品屬性：
產品名稱 | 10-Cl-BBQ |
規格 | 5 mg、25 mg |
貨號 | EY-01Y10683 |
Cas No.: 23982-76-5
別名: N/A
化學名: N/A
分子式: C18H9ClN2O
分子量: 304.73
溶解度: Soluble in DMSO
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Potent aryl hydrocarbon receptor (AhR) agonist, discovered as a screening hit (IC50 = 2.6 nM). Directly binds CD4+ T cells to induce AhR-dependent Tregs. Suppresses IL-17 production and prevents insulitis in NOD mice. In vivo half llife ~ 2 hours, orally bioavailable.Punj et al (2014) Benzimidazoisoquinolines: a new class of rapidly metabolized aryl hydrocarbon receptor (AhR) ligands that induce AhR-dependent Tregs and prevent murine graft-versus-host disease. PLoS One 9 e88726 PMID:24586378 |Ehrlich et al (2016) Activation of the aryl hydrocarbon receptor by 10-Cl-BBQ prevents insulitis and effector T cell development independently of Foxp3+ regulatory T Cells in nonobese diabetic mice. J.Immunol. 196 264 PMID:26573835
特別提醒公司產品僅供科研使用
