產品屬性：
產品名稱 | DAz-2 |
規格 | 1mg、5mg、10mg |
貨號 | EY-01Y10827 |
Cas No.: 1176905-54-6
別名: DCP-N3
化學名: 4-(3-azidopropyl)cyclohexane-1,3-dione
分子式: C9H13N3O2
分子量: 195.2
溶解度: 14 mg/ml in DMSO, 20 mg/ml in DMF, 25 mg/ml in Ethanol
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
DAz-2 is a cell-permeable chemical probe used to detect cysteine oxidation in proteins. Redox-sensitive cysteine residues in proteins may function as sensors of reactive oxygen species (ROS) and also serve as molecular switches, activating or deactivating proteins, following a change in oxidation state. Modification of protein function through the reversible oxidation of cysteine is emerging as a biologically relevant signal transduction mechanism. Sulfenic acid is the initial oxidation product of cysteine by relatively mild oxidizing agents such as hydrogen peroxide. Sulfenic acid can be reduced back to the free thiol or be further oxidized to sulfinic and sulfonic acids.[1] DAz-2 is a cell-permeable chemical probe that reacts specifically with sulfenic acid-modified proteins.[2] The azido group of DAz-2 provides a method for selective conjugation to phosphine- or alkynyl- derivatized reagents, such as biotin or various fluorophores, for subsequent analysis of the labeled proteins. Use of DAz-2 in HeLa cells followed by Staudinger ligation to biotin and subsequent LC-MS/MS analysis, led to the identification of 193 sulfenic acid-modified proteins having a diverse range of functions.[2]
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