產品屬性：
產品名稱 | CU-76 |
規格 | 1 mg、5 mg、10 mg |
貨號 | EY-01Y10866 |
Cas No.: 2400954-58-5
別名: N/A
化學名: N/A
分子式: C11H8F2IN5O2
分子量: 407.1
溶解度: DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:5): 0.1 mg/ml
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
CU-76 is an inhibitor of cyclic GMP-AMP synthase (cGAS; IC50 = 0.24 μM).1 It reduces DNA-, but not Sendai virus-, induced dimerization of IFN regulatory factor 3 in THP-1 cells, indicating selectivity for the cGAS DNA sensing pathway over the RIG-I-MAVS RNA sensing pathway. CU-76 decreases IFN-stimulatory DNA-induced production of IFN-β in THP-1 cells when used at concentrations of 10, 30, and 100 μM.1.Padilla-Salinas, R., Sun, L., Anderson, R., et al.Discovery of small-molecule cyclic GMP-AMP synthase inhibitorsJ. Org. Chem.85(3)1579-1600(2020)
特別提醒公司產品僅供科研使用
