產品屬性：
產品名稱 | ST 045849 |
規格 | 10 mg、50 mg |
貨號 | EY-01Y11447 |
Cas No.: 442665-87-4
別名: N/A
化學名: N/A
分子式: C23H27ClN2O3S
分子量: 446.99
溶解度: 44.7mg/mL in DMSO
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
O-GlcNAc transferase (OGT) inhibitor (IC50 = 53 μM). Reduces proliferation and viability of prostate cancer cells in vitro. Depletes intracellular alanine and decreases glucose consumption by cancer cells. Decreases markers of ER stress and apoptosis in pregnant diabetic mice and reduces neural tube defects in embryos from diabetic mice.Itkonen et al (2016) Inhibition of O-GlcNAc transferase activity reprograms prostate cancer cell metabolism. Oncotarget 7 12464 PMID:26824323 |Kim et al (2017) Impact of protein O-GlcNAcylation on neural tube malformation in diabetic embryopathy. Sci.Rep. 7 11107 PMID:28894244 |Kim et al (2014) Versatile O-GlcNAc transferase assay for high-throughput identification of enzyme variants, substrates, and inhibitors. Bioconjug.Chem. 25 1025 PMID:24866374
特別提醒公司產品僅供科研使用
