產品屬性：
產品名稱 | Amyloid-β (1-28) Peptide (human) (trifluoroacetate salt) |
規格 | 500μg、1mg、2.5mg、5mg |
貨號 | EY-01Y11933 |
Cas No.: N/A
別名: N/A
化學名: N/A
分子式: C145H209N41O46.XCF3COOH
分子量: 3262.5
溶解度: PBS (pH 7.2): 0.15 mg/ml
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Amyloid-β (1-28) (Aβ28) is a synthetic peptide that lacks 14 C-terminal amino acids and is more soluble than Aβ42 .1 Aβ28 forms fibrils and plaques in vitro that are similar to those formed by Aβ42 and induces learning deficits in a passive avoidance task in rats.2,3,4References1. Syme, C.D., Nadal, R.C., Rigby, S.E., et al. Copper binding to the amyloid-beta (Aβ) peptide associated with Alzheimer's disease. Folding, coordination geometry, pH dependence, stoichiometry, and affinity of Aβ(1-28): Insights from a range of complementary spectroscopic techniques. J. Biol. Chem. 279(18), 18169-18177 (2004).2. Kirschner, D.A., Inouye, H., Duffy, L.K., et al. Synthetic peptide homologous to β protein from Alzheimer disease forms amyloid-like fibrils in vitro. Proc. Natl. Acad. Sci. USA 84(19), 6953-6957 (1987).3. Burdick, D., Soreghan, B., Kwon, M., et al. Assembly and aggregation properties of synthetic Alzheimer's A4/β amyloid peptide analogs. J. Biol. Chem. 267(1), 546-554 (1992).4. Alvarez, X.A., Miguel-Hidalgo, J.J., Fernández-Novoa, L., et al. Intrahippocampal injections of the beta-amyloid 1-28 fragment induces behavioral deficits in rats. Methods Find. Exp. Clin. Pharmacol. 19(7), 471-479 (1997).
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