產品屬性：
產品名稱 | ACBI1 |
規格 | 100mg、250mg、500mg |
貨號 | EY-01Y12449 |
Cas No.: N/A
別名: N/A
化學名: N/A
分子式: C49H58FN9O7S
分子量: 936.1
溶解度: DMSO: ≥ 100 mg/mL (106.83 mM)
儲存條件: Store at -20°C, protect from light, stored under nitrogen
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 can induce anti-proliferative effects and apoptosis[1].DC50: 6 nM (SMARCA2), 11 nM (SMARCA4), 32 nM (PBRM1)[1][1]. Farnaby W, et al. BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design. Nat Chem Biol. 2019 Jul;15(7):672-680.
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