產品屬性：
產品名稱 | Amarogentin |
規格 | 1mg、5mg、10mg、25mg |
貨號 | EY-01Y12505 |
Cas No.: 21018-84-8
別名: N/A
化學名: N/A
分子式: C29H30O13
分子量: 586.5
溶解度: DMSO: 100 mg/ml,PBS (pH 7.2): 0.1 mg/ml
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Amarogentin is a secoiridoid glycoside that has been found in Swertia and has diverse biological activities, including anticancer, antidiabetic, and anti-leishmanial properties. It inhibits the growth of SNU-16 human gastric cancer cells (IC50 = 12.4 μM after 48 hours) and increases apoptosis when used at a concentration of 50 μM. Amarogentin (10-50 mg/kg, s.c.) dose-dependently reduces tumor growth in a SNU-16 nude mouse xenograft model. It reduces plasma glucose levels in a rat model of diabetes induced by streptozotocin in a dose-dependent manner and reverses the STZ-induced increase in soleus muscle levels of glucose transporter 4 (Glut4) when administered at a dose of 0.5 mg/kg. Amarogentin reduces parasite burden in the spleen of hamsters infected with L. donovani in a dose-dependent manner.
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