產品屬性：
產品名稱 | BI-9321 trihydrochloride |
規格 | 10mM*1 mL in DMSO、5mg、10mg、25mg、50mg、100mg |
貨號 | EY-01Y12547 |
Cas No.: 2387510-87-2
別名: N/A
化學名: N/A
分子式: C22H24Cl3FN4
分子量: 469.81
溶解度: DMSO: 250 mg/mL (532.13 mM)
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
BI-9321 trihydrochloride is a potent, selective and cellular active nuclear receptor-binding SET domain 3 (NSD3)-PWWP1 domain antagonist with a Kd value of 166 nM. BI-9321 trihydrochloride is inactive against NSD2-PWWP1 and NSD3-PWWP2. BI-9321 trihydrochloride specifically disrupts histone interactions of the NSD3-PWWP1 domain with an IC50 of 1.2 μM in U2OS cells[1].[1]. B?ttcher J, et al. Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3. Nat Chem Biol. 2019 Aug;15(8):822-829.
特別提醒公司產品僅供科研使用
