產品屬性：
產品名稱 | BB-Cl-Amidine hydrochloride |
規格 | 10mM*1mL in DMSO、1mg、5mg、10mg、25mg、50mg、100mg |
貨號 | EY-01Y12605 |
Cas No.: N/A
別名: N/A
化學名: N/A
分子式: C26H27Cl2N5O
分子量: 496.43
溶解度: DMSO: ≥ 100 mg/mL (201.44 mM)
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
BB-Cl-Amidine hydrochloride is a peptidylarginine deminase (PAD) inhibitor.PAD[1].Treatment with BB-Cl-amidine subtly reduces splenomegaly in MRL/lpr mice, while there is a trend towards increased circulating levels of anti-NET antibodies with PAD inhibitor treatment. However, neither PAD inhibitor affected body weight or total IgG levels. Indeed, treatment with both Cl-amidine and BB-Cl-amidine significantly improves endothelium-dependent vasorelaxation. The BB-Cl-amidine group also shows a strong trend towards downregulation of IRGs. Treatment with either Cl-amidine or BB-Cl-amidine significantly improves muzzle alopecia, in many cases preventing it entirely[1].Animal Model:MRL/lpr mice[1].[1]. Knight JS, et al. Peptidylarginine deiminase inhibition disrupts NET formation and protects against kidney, skin and vascular disease in lupus-prone MRL/lpr mice. Ann Rheum Dis. 2015 Dec;74(12):2199-206.
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