產品屬性：
產品名稱 | AZ9482 |
規格 | 1 mg、5 mg、10 mg、25 mg |
貨號 | EY-01Y12659 |
Cas No.: 1825345-33-2
別名: N/A
化學名: N/A
分子式: C26H22N6O2
分子量: 450.5
溶解度: DMF: 0.25mg/mL,DMSO: 0.15mg/mL
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
AZ9482 is a poly(ADP-ribose) polymerase (PARP) inhibitor (IC50s = 1, 1, 46, 640, 9, and 160 nM for PARP1, -2, -3, -6, TNKS1/PARP5a, and TNKS2, respectively).1 It induces centrosome declustering (EC50 = <18 nM) and a multipolar spindle phenotype in HeLa cells. AZ9482 inhibits the growth of OCI-LY19 diffuse large B cell lymphoma (DLBCL) cells (GI50 = 3 nM).1.Johannes, J.W., Almeida, L., Daly, K., et al.Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clusteringBioorg. Med. Chem. Lett.25(24)5743-5747(2015)
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