產品屬性：
產品名稱 | BIBF 1202 |
規格 | 10mM*1mL in DMSO、1mg、5mg、10mg、50mg |
貨號 | EY-01Y12837 |
Cas No.: 894783-71-2
別名: N/A
化學名: N/A
分子式: C30H31N5O4
分子量: 525.6
溶解度: DMSO: ≥ 45 mg/mL (85.62 mM)
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
BIBF 1202 is the carboxylate metabolite of BIBF 1120 which inhibits VEGFR2 kinase with an IC50 of 62 nM.IC50: 62 nM (VEGFR2)[1]The major metabolic pathway for BIBF 1120 is methyl ester cleavage to BIBF 1202. Subsequently, the free carboxyl group of BIBF 1202 is glucuronidated to 1-O-acylglucuronide[2].[1]. Hilberg F, et al. BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumorefficacy. Cancer Res. 2008 Jun 15;68(12):4774-82.
[2]. Stopfer P, et al. Pharmacokinetics and metabolism of BIBF 1120 after oral dosing to healthy male volunteers. Xenobiotica. 2011 Apr;41(4):297-311.
特別提醒公司產品僅供科研使用
