產品屬性：
產品名稱 | AZ Dyrk1B 33 |
規格 | 10 mg |
貨號 | EY-01Y12897 |
Cas No.: 1679330-37-0
別名: N/A
化學名: N/A
分子式: C19H16N4
分子量: 300.36
溶解度: Soluble in DMSO
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Potent and selective ATP-competitive Dyrk1B kinase inhibitor (IC50 = 7 nM); displays distinct cellular effects when compared to DYRK1B knockdown through siRNA. Demonstrates cellular in vitro activity (IC50 = 194 nM). Exhibits better selectivity than AZ 191 ; displays no off-target effects against a panel of 124 kinases tested (no kinase was inhibited above 50% at 1 μM).Kettle et al (2015) Discovery and optimization of a novel series of Dyrk1B kinase inhibitors to explore a MEK resistance hypothesis. J.Med.Chem. 58 2834 PMID:25738750
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