產品屬性：
產品名稱 | Bozitinib |
規格 | 5mg、10mg、25mg、50mg、100mg、200mg、500mg |
貨號 | EY-01Y12889 |
Cas No.: 1440964-89-5
別名: N/A
化學名: N/A
分子式: C20H15F3N8
分子量: 424.38
溶解度: DMSO: 50 mg/mL (117.82 mM)
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Bozitinib (PLB-1001) is a highly selective c-MET kinase inhibitor with blood-brain barrier permeability. Bozitinib (PLB-1001) is a ATP-competitive small-molecule inhibitor, binds to the conventional ATP-binding pocket of the tyrosine kinase superfamily[1].Bozitinib (PLB-1001) (30 μM; 6 hours) inhibits the phosphorylation of MET and STAT3, has a robust inhibitory effect of PLB-1001 on MET and its downstream signaling pathways.Western Blot Analysis[1] Cell Line:Human astrocytes (HA) cells[1]. Hu H, et al. Mutational Landscape of Secondary Glioblastoma Guides MET-Targeted Trial in Brain Tumor. Cell. 2018 Nov 29;175(6):1665-1678.e18.
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