產品屬性：
產品名稱 | BRD 6989 |
規格 | 10 mg、50 mg |
貨號 | EY-01Y12938 |
Cas No.: 642008-81-9
別名: N/A
化學名: N/A
分子式: C16H16N4
分子量: 264.33
溶解度: Soluble in DMSO
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Binds and inhibits Cdk8 in complex with cyclin C (IC50 ~ 200 nM). Enhances IL-10 production in activated human and murine macrophages and dendritic cells (EC50 is approximately 1 μM for IL-10 production in bone marrow-derived dendritic cells). Also inhibits CDK19 in complex with cyclin C.Johannessen et al (2017) Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells. Nat.Chem.Biol. 13 1102 PMID:28805801
特別提醒公司產品僅供科研使用
