產品屬性：
產品名稱 | D-threo-PPMP (hydrochloride) |
規格 | 10 mg |
貨號 | EY-01Y13039 |
Cas No.: 139889-65-9
別名: N/A
化學名: N/A
分子式: C29H50N2O3.HCl
分子量: 511.2
溶解度: Ethanol: Soluble,Methanol: Soluble
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
D-threo-PPMP is a glucosylceramide (GlyCer) synthetase inhibitor.1,2 It is the active enanantiomer and enzymatic inhibitory component of the racemic DL-threo-PPMP . In MDCK kidney epithelial cells, D-threo-PPMP induces a 70% reduction in cell growth in vitro at 20 μM and significantly inhibits DNA synthesis at 3 μM.3 [Matreya, LLC. Catalog No. 1865]1.Shen, W., Henry, A.G., Paumier, K.L., et al.Inhibition of glucosylceramide synthase stimulates autophagy flux in neuronsJ. Neurochem.129(5)884-894(2014)
2.Lee, L., Abe, A., and Shayman, J.A.Improved inhibitors of glucosylceramide synthaseJ. Biol. Chem.274(21)14662-14669(1999)
3.Abe, A., Inokuchi, J.-i., Jimbo, M., et al.Improved inhibitors of glucosylceramide synthaseJ. Biochem.111(2)191-196(1992)
特別提醒公司產品僅供科研使用
