產品屬性：
產品名稱 | CDK9 Antagonist-1 |
規格 | 100mg、250mg、500mg |
貨號 | EY-01Y13157 |
Cas No.: N/A
別名: N/A
化學名: N/A
分子式: C39H36N6O10
分子量: 748.74
溶解度: Soluble in DMSO
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
CDK9 Antagonist-1 (compounds 11c) is a potent and selective CDK9 degrader based on PROTAC, with an IC50 of 17 μM in MCF-7 cell lines. Natural product Wogonin binds ubiquitin E3 ligase cereblon (CRBN) via a linker to form PROTAC[1].
CDK9|17 μM (IC50, MCF-7 cells)
[1]. Bian J , et al. Discovery of Wogonin-based PROTACs against CDK9 and capable of achieving antitumor activity. Bioorg Chem. 2018 Dec;81:373-381.
特別提醒公司產品僅供科研使用
