產品屬性：
產品名稱 | CRT 0105950 |
規格 | 10 mg |
貨號 | EY-01Y13177 |
Cas No.: 1661845-86-8
別名: N/A
化學名: N/A
分子式: C21H16ClN3OS
分子量: 393.89
溶解度: Soluble in DMSO
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Potent LIMK1/2 inhibitor (IC50 values are 0.3 and 1 nM at LIMK 1 and 2, respectively). Disrupts microtubule organization, inhibits cofilin phosphorylation and increases α-tubulin acetylation in vitro.Charles et al (2015) Discovery, development, and SAR of aminothiazoles as LIMK inhibitors with cellular anti-invasive properties. J.Med.Chem. 58 8309 PMID:26356364 |Mardilovich et al (2015) LIM kinase inhibitors disrupt mitotic microtubule organization and impair tumor cell proliferation. Oncotarget. 6 38469 PMID:26540348
特別提醒公司產品僅供科研使用
