產品屬性：
產品名稱 | AHU377-d4 |
規格 | 500 μg、1 mg、5 mg |
貨號 | EY-01Y13247 |
Cas No.: 1884269-07-1
別名: N/A
化學名: N/A
分子式: C24H25D4NO5
分子量: 415.5
溶解度: Chloroform: Slightly Soluble,DMSO: Slightly Soluble,Methanol: Slightly Soluble
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
AHU377-d4 is intended for use as an internal standard for the quantification of AHU377 by GC- or LC-MS. AHU377 is a methyl ester prodrug form of the neprilysin inhibitor LBQ657 .1 It increases plasma levels of atrial natriuretic factor (ANF) in conscious rats and anesthetized dogs when administered at doses of 10 and 30 mg/kg, respectively. AHU377 (30 mg/kg) increases ANF-induced urinary sodium excretion in anesthetized rats. Formulations containing AHU377 in combination with valsartan have been used in the treatment of mild to moderate hypertension and chronic heart failure.
1.Ksander, G.M., Ghai, R.D., deJesus, R., et al.Dicarboxylic acid dipeptide neutral endopeptidase inhibitorsJ. Med. Chem.38(10)1689-1700(1995)
特別提醒公司產品僅供科研使用
