產品屬性：
產品名稱 | AP39 |
規格 | 10 mM * 1 mL in DMSO、5mg、10mg、25mg、50mg、100mg |
貨號 | EY-01Y13227 |
Cas No.: 1429173-57-8
別名: N/A
化學名: N/A
分子式: C37H38O2PS3
分子量: 641.9
溶解度: DMF: 5 mg/ml,DMSO: 20 mg/ml,Ethanol: 16 mg/ml,PBS (pH 7.2): 1 mg/ml
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
AP39 is a compound used to increase the levels of hydrogen sulfide (H2S) within mitochondria. It consists of a mitochondria-targeting motif (triphenylphosphonium) coupled to an H2S-donating moiety (dithiolethione) by an aliphatic linker. AP39 (30-300 nM) dose-dependently increases H2S levels in endothelial cells, predominantly in mitochondrial regions. It stimulates mitochondrial electron transport and improves cellular bioenergetic function at lower concentrations (30-100 nM), while having an inhibitory effect at 300 nM. Under oxidative stress conditions induced by glucose oxidase, AP39 has antioxidant and cytoprotective effects. AP39 is effective in vivo, inhibiting voltage-dependent T-type calcium channels and improving hemodynamic parameters in rats.
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