產品屬性：
產品名稱 | CAY10471 Racemate |
規格 | 10mM*1mL in DMSO、5mg、10mg、25mg、50mg、100mg |
貨號 | EY-01Y13787 |
Cas No.: 844639-57-2
別名: N/A
化學名: N/A
分子式: C21H21FN2O4S
分子量: 416.47
溶解度: DMSO: 150 mg/mL (360.17 mM)
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
CAY10471 Racemate (TM30089 Racemate) is a potent and highly selective prostaglandin D2 receptor CRTH2 antagonist, with a Ki of 0.6 nM for hCRTH2, selective over human thromboxane A2 receptor TP (Ki, >10000 nM) or PGD2 receptor DP (Ki, 1200 nM). CAY10471 Racemate also has effect on mouse and rat orthologs of CRTH2[1].Ki: 0.6 nM (CRTH2), 1200 nM (DP)[1]CAY10471 Racemate (Compound 13) inhibits PGD2-induced inositol phosphate or cAMP formation, suppresses β-arrestin translocation with IC50s of 12 and 3 nM, respectively[1].[1]. Ulven T, et al. Minor structural modifications convert the dual TP/CRTH2 antagonist ramatroban into a highly selective and potent CRTH2 antagonist. J Med Chem. 2005 Feb 24;48(4):897-900.
特別提醒公司產品僅供科研使用
