產品屬性：

Cas No.: 55179-31-2

別名: N/A

化學名: N/A

分子式: C20H23N3O2

分子量: 337.4

溶解度: Chloroform: slightl soluble,DMSO: Slightly Soluble,Methanol: Slightly Soluble

儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping ConditionEvaluation sample solution : ship with blue ice

All other available size: ship with RT , or blue ice upon request

產品描述：

Bitertanol is a broad-spectrum triazole fungicide that is active against a variety of fungi, including V. inaequalis and V. pirina, which are responsible for apple and pear scab, respectively, as well as S. mors-uvae and P. ribis, which are responsible for American gooseberry mildew and leaf spot in black currants, respectively.1 It is active against isolates of V. inaequalis (MICs = 0.6 and 1 μg/ml) but repeated use leads to resistance and cross-resistance (MICs = 9.8-13 μg/ml for bitertanol-resistant isolates).2 Bitertanol inhibits the cytochrome P450 (CYP450) isoform CYP3A4 (IC50 = 2.74 μM) and inhibits androgenic activity induced by the androgen receptor agonist DHT in a yeast two-hybrid assay (IC50 = 79.85 μM).3 In rats, bitertanol (10-300 mg/kg, i.p.) increases operant responding on one- and five-minute fixed interval schedules with no effect on motor activity.41.Birch, P.A., Rose, P.W., and Wainwright, A.A broad spectrum fungicide of the triazole group for use in pome and bush fruitBrit. Crop Prot. Conf. - Pests and Dis., Proc.11(2)545-554(1981)

2.Hildebrand, P.D., Lockhart, C.L., Newberry, R.J., et al.Resistance of Venturia inaequalis to bitertanol and other demethylation-inhibiting fungicidesCan. J. Plant Path.10(4)311-316(1988)

3.Lv, X., Pan, L., Wang, J., et al.Effects of triazole fungicides on androgenic disruption and CYP3A4 enzyme activityEnviron. Pollut.222(2016)504-512(2017)

4.Allen, A.R., and MacPhail, R.C.Bitertanol, a triazole fungicide, increases operant responding but not motor activityNeurotoxicol. Teratol.15(4)237-242(1993)
特別提醒公司產品僅供科研使用