產品屬性：
產品名稱 | Barbadin |
規格 | 10mM*1mL in DMSO、1mg、2mg、5mg、10mg、50mg |
貨號 | EY-01Y13879 |
Cas No.: 356568-70-2
別名: N/A
化學名: N/A
分子式: C19H15N3OS
分子量: 333.41
溶解度: DMSO: 50 mg/mL (149.97 mM)
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Barbadin is a novel and selective β-arrestin/β2-adaptin interaction inhibitor, has IC50 values of 19.1 μM for β-arrestin1 and 15.6 μM for β-arrestin2. Barbadin blocks agonist-promoted endocytosis of the prototypical β2-adrenergic, V2-vasopressin and angiotensin-II type-1 receptors[1].[1]. Beautrait A, et al. A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling. Nat Commun. 2017 Apr 18;8:15054. doi: 10.1038/ncomms15054.
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