產品屬性：
產品名稱 | AZD-8529 mesylate |
規格 | 10mM*1 mL in DMSO、5mg、10mg、25mg、50mg、100mg |
貨號 | EY-01Y13960 |
Cas No.: 1314217-69-0
別名: N/A
化學名: N/A
分子式: C25H28F3N5O6S
分子量: 583.58
溶解度: DMSO: 41.67 mg/mL (71.40 mM)
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
AZD-8529 mesylate is a potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2, with an EC50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes[1].AZD-8529 mesylate potentiates the effects of glutamate at mGluR2 with an EC50 of 195 nM [1].AZD-8529 mesylate does not elicit antagonist responses on mGluRs at 25 μM[1].AZD-8529 mesylate (0.3-mg/kg, i.m.) reduces nicotine priming-induced and cue-induced reinstatement in squirrel monkeys[1]. AZD-8529 mesylate (30 mg/kg; i.p.) decreases the increased extracellular dopamine induced by nicotine in accumbens shell of freely-moving rats[1].
特別提醒公司產品僅供科研使用
