產品屬性：
產品名稱 | Carnostatine hydrochloride |
規格 | 1mg、5mg、10mg、25mg、50mg、100mg、200mg、500mg |
貨號 | EY-01Y14149 |
Cas No.: N/A
別名: N/A
化學名: N/A
分子式: C10H17ClN4O4
分子量: 292.72
溶解度: H2O: ≥ 250 mg/mL (854.06 mM)
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Carnostatine hydrochloride (SAN9812 hydrochloride) is a potent and selective carnosinase 1 (CN1) inhibitor with a Ki of 11 nM for human recombinant CN1. Carnostatine hydrochloride can be used for the treatment of diabetic nephropathy (DN)[1].Carnostatine (SAN9812) also inhibits CN1 activity in human serum and serum of transgenic mice-overexpressing human CN1. Carnostatine, with an IC50 value of 18 nM on human recombinant CN1 at a carnosine concentration of 200 μM, i.e., close to the Km of 190 μM[1].Subcutaneous administration of 30 mg/kg Carnostatine (SAN9812) leads to a sustained reduction in circulating CN1 activity in human CN1 transgenic (TG) mice. Simultaneous administration of Carnosine and Carnostatine increases carnosine levels in plasma and kidney by up to 100-fold compared to treatment-na?ve CN1-overexpressing mice[1].
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