產品屬性：
產品名稱 | Biperiden-d5 |
規格 | 1 mg、5 mg |
貨號 | EY-01Y14215 |
Cas No.: N/A
別名: N/A
化學名: N/A
分子式: C21H24D5NO
分子量: 316.5
溶解度: Acetonitrile: soluble,DMSO: soluble,Methanol: soluble
儲存條件: -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Biperiden-d5 is intended for use as an internal standard for the quantification of biperiden by GC- or LC-MS. Biperiden is an antagonist of muscarinic acetylcholine receptors (mAChRs; IC50s = 0.48, 6.3, 3.9, 2.4, and 6.3 nM for M1-5 receptors, respectively).1 It increases spontaneous and electrically evoked dopamine release and electrically evoked acetylcholine (ACh) release from rabbit caudate nucleus slices preincubated with dopamine.2 Biperiden (10 μM) also inhibits NMDA-induced ACh release in rabbit caudate nucleus slices.3 Biperiden (0.01-1.0 mg/kg) reduces physostigmine-induced tremor in rats.4 Formulations containing biperiden have been used as an adjuvant treatment for Parkinson’s disease.1.Bolden, C., Cusack, B., and Richelson, E.Antagonism by antimuscarinic and neuroleptic compounds at the five cloned human muscarinic cholinergic receptors expressed in Chinese hamster ovary cellsJ. Pharmacol. Exp. Ther.260(2)576-580(1992)
2.Jackisch, R., Huang, H.Y., Reimann, W., et al.Effects of the antiparkinsonian drug budipine on neurotransmitter release in central nervous system tissue in vitroJ. Pharmacol. Exp. Ther.264(2)889-898(1993)
3.Jackisch, R., Kruchen, A., Sauermann, W., et al.The antiparkinsonian drugs budipine and biperiden are use-dependent (uncompetitive) NMDA receptor antagonistsEur. J. Pharmacol.264(2)207-211(1994)
4.Gothóni, P., Lehtinen, M., and Fincke, M.Drugs for Parkinson’s disease reduce tremor induced by physostigmineNaunyn Schmiedebergs Arch. Pharmacol.323(3)205-210(1983)
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