產品屬性：
產品名稱 | BAY 61-3606 (hydrochloride) |
規格 | 1mg、5mg、10mg |
貨號 | EY-01Y14165 |
Cas No.: 1615197-10-8
別名: N/A
化學名: N/A
分子式: C20H18N6O3?HCl
分子量: 426.9
溶解度: DMF: 1 mg/mL,DMSO: 30 mg/mL,DMSO:PBS (pH 7.2) (1:30): 0.03 mg/mL,Ethanol: 0.1 mg/mL
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
BAY 61-3606 is a cell-permeable, reversible inhibitor of spleen tyrosine kinase (Syk; Ki = 7.5 nM; IC50 = 10 nM). It is 700 to >1,000-fold more selective for Syk over Src, Lyn, Fyn, Itk, and Btk. BAY 61-3606 can inhibit degranulation (IC50 = 5-46 nM) and block cytokine release from mast cells. At 3 mg/kg, oral administration of BAY 61-3606 to rats was shown to suppress antigen-induced passive cutaneous anaphylactic reaction, bronchoconstriction, and bronchial edema. It can also sensitize MCF-7 breast cancer cells to TNF-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis by inhibiting Cdk9. This compound has been used in a pre-clinical model to explore the feasibility of targeting Syk in the treatment of retinoblastoma.
特別提醒公司產品僅供科研使用
