產品屬性：
產品名稱 | Amodiaquine-d10 |
規格 | 1mg |
貨號 | EY-01Y14278 |
Cas No.: 1189449-70-4
別名: N/A
化學名: N/A
分子式: C20H12ClD10N3O
分子量: 365.9
溶解度: Chloroform: soluble,Methanol: soluble
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Amodiaquine-d10 is intended for use as an internal standard for the quantification of amodiaquine by GC- or LC-MS. Amodiaquine is a prodrug form of the antimalarial compound N-desethyl amodiaquine .1,2 It is active against several strains of P. falciparum in vitro (EC50s = 0.23-0.52 nM) and exhibits a synergistic effect when used in combination with N-desethyl amodiaquine.1 Amodiaquine dose-dependently inhibits development of parasitemia in a mouse model of P. berghei infection.3|1. Mariga, S.T., Gil, J.P., Sisowath, C., et al. Synergism between amodiaquine and its major metabolite, desethylamodiaquine, against Plasmodium falciparum in vitro. Antimicrob. Agents Chemother. 48(11), 4089-4096 (2004).|2. Sá, J.M., Chong, J.L., and Wellems, T.E. Malaria drug resistance: New observations and developments. Essays Biochem. 51, 137-160 (2014).|3. Jacobs, R.L., Alling, D.W., and Cantrell, W.F. An evaluation of antimalarial combinations against Plasmodium berghei in the mouse. J. Parasitol. 49(6), 920-925 (1963).
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