產品屬性：
產品名稱 | Benastatin B |
規格 | 1 mg |
貨號 | EY-01Y14666 |
Cas No.: 138968-86-2
別名: N/A
化學名: N/A
分子式: C30H30O7
分子量: 502.6
溶解度: N/A
儲存條件: -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Benastatin B is a polyketide synthase-derived benastatin that has been found in Streptomyces and has diverse biological activities.1,2,3 It inhibits glutathione S-transferase (GST; Ki = 3.7 μM for the rat liver enzyme).2 Benastatin B also inhibits the transglycosylase activity of A. baumannii, C. difficile, E. coli, and S. aureus recombinant penicillin-binding proteins (PBPs; IC50s = 16, 53.3, 30.7, and 31.6 μM, respectively).3 It is active against several bacteria, including methicillin-resistant S. aureus (MRSA; MIC = 3.12 μg/ml).21.Xu, Z., Schenk, A., and Hertweck, C.Molecular analysis of the benastatin biosynthetic pathway and genetic engineering of altered fatty acid-polyketide hybridsJ. Am. Chem. Soc.129(18)6022-6030(2007)
2.Aoyagi, T., Aoyama, T., Kojima, F., et al.Benastatins A and B, new inhibitors of glutathione S-transferase, produced by Streptomyces sp. MI384-DF12. I. Taxonomy, production, isolation, physico-chemical properties and biological activitiesJ. Antibiot. (Tokyo)45(9)1385-1390(1992)
3.Wu, W.-S., Cheng, W.-C., Cheng, T.-J.R., et al.Affinity-based screen for inhibitors of bacterial transglycosylaseAm. Chem. Soc.140(8)2752-2755(2018)
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