產品屬性：
產品名稱 | Argatroban-d3 (hydrochloride) |
規格 | 1 mg、5 mg |
貨號 | EY-01Y14783 |
Cas No.: 1356847-56-7
別名: N/A
化學名: N/A
分子式: C23H33D3N6O5S.HCl
分子量: 548.1
溶解度: DMF: soluble,DMSO: soluble,Methanol: soluble
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Argatroban-d3 is intended for use as an internal standard for the quantification of argatroban by GC- or LC-MS. Argatroban is a reversible inhibitor of thrombin (IC50s = 0.01 and 0.09 μM for the free and clot-bound forms, respectively).1 It is selective for thrombin over factor Xa, trypsin, plasmin, and tissue plasminogen activator (Kis = 0.0045, 53, 0.19, 25.7, and 87.7 μM, respectively). It inhibits thrombin-induced platelet aggregation in washed isolated guinea pig platelets with an IC50 value of 0.077 μM.2 Argatroban (3.2 mg/kg, s.c.) decreases thrombus formation in a guinea pig model of iron chloride-induced arterial thrombosis. Formulations containing argatroban have been used in the prevention or treatment of thrombosis in patients with heparin-induced thrombocytopenia.1.Park, H.D., Lee, S.H., Kim, T.H., et al.Antithrombotic effects of LB30870, a potent, orally active, selective and direct thrombin inhibitor, and pharmacokinetics of its prodrugBioorganic & Medicinal Chemistry Letters23(17)4779-4784(2013)
2.Kato, Y., Kita, Y., Hirasawa-Taniyama, Y., et al.Inhibition of arterial thrombosis by a protease-activated receptor 1 antagonist, FR171113, in the guinea pigEur. J. Pharmacol.473(2-3)163-169(2003)
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