產品屬性：
產品名稱 | Benproperine phosphate |
規格 | 10mM*1 mL in DMSO、100 mg |
貨號 | EY-01Y15001 |
Cas No.: 19428-14-9
別名: N/A
化學名: N/A
分子式: C21H30NO5P
分子量: 407.44
溶解度: DMSO : 250 mg/mL (613.59 mM)
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Benproperine phosphate is an orally active, potent actin-related protein 2/3 complex subunit 2 (ARPC2) inhibitor. Benproperine phosphate attenuates the actin polymerization rate of action polymerization nucleation by impairing Arp2/3 function. Benproperine phosphate has the potential for a cough suppressant and suppresses cancer cell migration and tumor metastasis[1].Benproperine phosphate (20-120 μM; for 24?hours) inhibits cell viability in a dose-dependent manner[1]. Benproperine phosphate (10 μM; for 24?hours) significantly inhibits the migration of various types of cancer cells and inhibits the migration and invasion of DLD-1, AsPC-1 cells with IC50 values of 1-2?μM. Benproperine phosphate (10 μM; for 24?hours) does not affect cortactin-rich lamellipodium in MCF-10A cells[1].Benproperine phosphate (50, 100?mg/kg; oral gavage; 5?days per week for 4?weeks) inhibits primary pancreatic tumor growth[1]. Benproperine phosphate shows a marked decrease in the lung metastasis of AsPC-1 cells (56.1% inhibition) in mouse. Benproperine phosphate significantly suppressed the liver metastasis of HCT-116 cells by 78.9% and DLD-1 cells by 78.2%[1].
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