產品屬性：
產品名稱 | BIBB 515 |
規格 | 5mg、10mg、50mg、100mg |
貨號 | EY-01Y14975 |
Cas No.: 156635-05-1
別名: N/A
化學名: N/A
分子式: C22H21ClN2O2
分子量: 380.9
溶解度: DMF: 0.30 mg/ml,DMSO: 0.25 mg/ml,Ethanol: 0.15 mg/ml
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
2,3-Oxidosqualene cyclase (OSC) is an important enzyme in the biosynthesis of animal, plant, and fungal sterols. OSC catalyzes the conversion of (3S)-2,3-oxidosqualene to lanosterol, a precursor to cholesterol, in mammals and fungi. BIBB 515 is a selective and potent inhibitor of OSC in vivo with an ED50 value of 0.2-0.5 and 0.36-33.3 mg/kg in rats and mice, respectively. Total cholesterol was reduced by 19% in normolipemic hamsters at a dose of 55 mg/kg/day for 11 days and 25% in hyperlipemic hamsters at a dose of 148 mg/kg/day for 25 days.
特別提醒公司產品僅供科研使用
