產品屬性：
產品名稱 | AS1708727 |
規格 | 5 mg、10 mg、25 mg、50 mg、100 mg |
貨號 | EY-01Y15013 |
Cas No.: 1253226-93-5
別名: N/A
化學名: N/A
分子式: C24H24Cl2N2O2
分子量: 443.37
溶解度: DMSO : 41.67 mg/mL (93.98 mM; Need ultrasonic)
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
AS1708727 is an orally active Foxo1 inhibitor, with EC50 values of 0.33 μM and 0.59 μM for G6Pase and PEPCK, respectively[1].AS1708727 suppresses increases in blood glucose level by inhibiting gluconeogenic gene expression[1].AS1708727 (30 to 300 mg/kg, orally) reduces both blood glucose and triglyceride levels, exhibiting anti-diabetic effects[1].[1]. Hirotsugu Tanaka, et al. Effects of the Novel Foxo1 Inhibitor AS1708727 on Plasma Glucose and Triglyceride Levels in Diabetic Db/Db Mice. Eur J Pharmacol. 2010 Oct 25;645(1-3):185-91.
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