產品屬性：

Cas No.: 65854-97-9

別名: N/A

化學名: N/A

分子式: C15H2D10N2O2

分子量: 262.3

溶解度: DMSO: slightly soluble,Methanol: slightly soluble

儲存條件: -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping ConditionEvaluation sample solution : ship with blue ice

All other available size: ship with RT , or blue ice upon request

產品描述：

Phenytoin-d10 is intended for use as an internal standard for the quantification of phenytoin by GC- or LC-MS. Phenytoin is an anticonvulsant agent and active metabolite of fosphenytoin . Phenytoin is formed from fosphenytoin by tissue phosphatases.1 It inhibits neuronal voltage-gated sodium channels in a voltage-dependent manner.2 Phenytoin reduces the neuronal firing frequency and decreases the amplitude of excitatory post-synaptic potentials (EPSPs) in electrically stimulated rat corticostriatal slices (EC50s = 42.8 and 33.5 μM, respectively).3 It protects against seizures induced by maximal electroshock (MES) in mice (ED50 = 10 mg/kg).4 Formulations containing phenytoin have been used in the treatment of tonic-clonic seizures and status epilepticus.1.Boucher, B.A.Fosphenytoin: A novel phenytoin prodrugPharmacotherapy16(5)777-791(1996)

2.Yaari, Y., Selzer, M.E., and Pincus, J.H.Phenytoin: Mechanisms of its anticonvulsant actionAnn. Neurol.20(2)171-184(1986)

3.Calabresi, P., Centonze, D., Marfia, G.A., et al.An in vitro electrophysiological study on the effects of phenytoin, lamotrigine and gabapentin on striatal neuronsBr. J. Pharmacol.126(3)689-696(1999)

4.Brouillette, W.J., Jestkov, V.P., Akhtar, M.S., et al.Bicyclic hydantoins with a bridgehead nitrogen. Comparison of anticonvulsant activities with binding to the neuronal voltage-dependent sodium channelJ. Med. Chem.37(20)3289-3293(1994)
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