產品屬性：
產品名稱 | Chroman 1 (hydrochloride hydrate) |
規格 | 1 mg、5 mg、10 mg |
貨號 | EY-01Y15298 |
Cas No.: N/A
別名: N/A
化學名: N/A
分子式: C24H28N4O4·2HCl [XH2O]
分子量: 527.4
溶解度: DMSO: 100 mM,Water: 5 mM
儲存條件: -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Chroman 1 is an inhibitor of Rho-associated kinase 2 (ROCK2; IC50 = <1 nM).1 It is selective for ROCK2 over protein kinase A (PKA) and Cdc42-binding kinase (MRCKα; IC50s = 1,740 and 127 nM, respectively). Chroman 1 inhibits phosphorylation of myosin light chain (MLC) in a cell-based assay (IC50 = <4 nM).1.Chen, Y.T., Vojkovsky, T., Fang, X., et al.Asymmetric synthesis of potent chroman-based Rho kinase (ROCK-II) inhibitorsMed. Chem. Commun.2(1)73-75(2011)
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