產品屬性：
產品名稱 | D8-MMAD |
規格 | 10mM*1mL in DMSO、1mg、5mg、10mg、50mg、100mg |
貨號 | EY-01Y15332 |
Cas No.: N/A
別名: N/A
化學名: N/A
分子式: C41H58D8N6O6S
分子量: 779.11
溶解度: DMSO: ≥ 100 mg/mL (128.35 mM)
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
D8-MMAD is a deuterated form of MMAD, which is a microtubule disrupting agent.IC50 & Target: Tubulin[1]MMAD (Monomethyl Dolastatin 10) is coupled through a stable oxime-ligation process to yield several near-homogenous antibody-drug conjugates (ADCs) with a drug-to-antibody ratio of ~2.0. The resulting conjugates demonstrate good pharmacokinetic properties, potent in vitro cytotoxic activity against HER2+ cancer cells. When compared with ADCs prepared by cysteine alkylation following native interchain disulfide reduction, site-specific unnatural-amino-acid-based ADCs are shown to have increased in vitro cytotoxicity[1].The resulting antibody-drug conjugates (ADCs) demonstrate complete tumour regression in rodents. They also have an improved toxicology profile in rats[1].[1]. Chudasama V, et al. Recent advances in the construction of antibody-drug conjugates. Nat Chem. 2016 Feb;8(2):114-9.
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