產品屬性：
產品名稱 | CYP17-IN-1 |
規格 | 100mg、250mg、500mg |
貨號 | EY-01Y15537 |
Cas No.: 2093317-51-0
別名: N/A
化學名: N/A
分子式: C18H17FN2S
分子量: 312.4
溶解度: Soluble in DMSO
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
CYP17-IN-1 (compound 9c) is a potent and orally active CYP17 inhibitor against rat and human CYP17 with IC50s of 15.8 and 20.1 nM[1].IC50: 15.8 nM (Rat CYP17), 20.1 nM (Human CYP17)[1]CYP17-IN-1 (compound 9c) exhibits an IC50 value of 8.5 μM against CYP3A4[1].CYP17-IN-1 (compound 9c) reduces plasma testosterone level in a dose-dependent manner in Sprague-Dawley rats[1].[1]. Wang M, et al. Discovery of novel 1,2,3,4-tetrahydrobenzo[4, 5]thieno[2, 3-c]pyridine derivatives as potent and selective CYP17 inhibitors. Eur J Med Chem. 2017 May 26;132:157-172.
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