產品屬性：
產品名稱 | D-Lin-MC3-DMA |
規格 | 10mM*1mL in DMSO、5mg、10mg、25mg、50mg、100mg |
貨號 | EY-01Y15728 |
Cas No.: 1224606-06-7
別名: N/A
化學名: N/A
分子式: C43H79NO2
分子量: 642.09
溶解度: DMSO: 250 mg/mL (389.35 mM); Ethanol: ≥ 60 mg/mL (93.44 mM)
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.Lipid nanoparticles (LNPs) containing distearoylphosphatidlycholine (DSPC), and ionizableamino-lipids such as dilinoleylmethyl-4-dimethylaminobutyrate (DLin-MC3-DMA) are potent siRNA delivery vehicles in vivo. LNP-siRNA systems optimize to achieve maximum gene silencing potency in hepatocytesfollowing IV administration in mice contain DLin-MC3-DMA (MC3), DSPC, cholesterol and a polyethyleneglycol (PEG)-lipid at mole ratios of 50/10/38.5/1.5. DLin-MC3-DMA exhibits an optimized pKa value that leads to dramatically enhanced potency[1].[1]. Kulkarni JA, et al. Design of lipid nanoparticles for in vitro and in vivo delivery of plasmid DNA. Nanomedicine. 2017 May;13(4):1377-1387.
特別提醒公司產品僅供科研使用
