產品屬性：
產品名稱 | CL2-SN-38 (dichloroacetic acid salt) |
規格 | 1 mg、5 mg、10 mg、25 mg |
貨號 | EY-01Y15773 |
Cas No.: N/A
別名: N/A
化學名: N/A
分子式: C82H106N12O23.XC2H2Cl2O2
分子量: 1627.8
溶解度: DMSO: >1mg/mL,Ethanol: >1mg/mL
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
CL2-SN-38 is a cleavable linker-based antibody-drug conjugate (ADC) containing the topoisomerase I inhibitor SN-38 and a maleimidocaproyl linker.1 CL2-SN-38 has been linked to tumor-selective human monoclonal antibodies, such as anti-CEACAM5 (hMN-14) to target SN-38 to tumor sites and improve its solubility. CL2-SN-38 linked to hMN-14 binds (Kd = 1.4 nM) and is cytotoxic to LoVo human colon adenocarcinoma cells (IC50 = 5.3 nM). CL2-SN-38 linked to hMN-14 increases survival in a colon carcinoma mouse model of lung metastasis.1.Moon, S., Govindan, S.V., Cardillo, T.M., et al.Antibody conjugates of 7-ethyl-10-hydroxycamptothecin (SN-38) for targeted cancer chemotherapyJ. Med. Chem.51(21)6916-6926(2008)
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