產品屬性：
產品名稱 | Butenafine-13C-d3 (hydrochloride) |
規格 | 500 μg、1 mg、5 mg、10 mg |
貨號 | EY-01Y15876 |
Cas No.: N/A
別名: N/A
化學名: N/A
分子式: C22[13C]H24D3N·HCl
分子量: 357.9
溶解度: DMF: soluble,DMSO: soluble,Methanol: soluble
儲存條件: -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Butenafine-13C-d3 is intended for use as an internal standard for the quantification of butenafine by GC- or LC-MS. Butenafine is a benzylamine antifungal agent that has broad-spectrum activity against 87 strains of dermatophytes (MICs = 0.0015-0.05 μg/ml), 15 strains of Aspergillus (MICs = 0.025-0.78 μg/ml), 4 strains of Cryptococcus (MICs = 0.78-1.56 μg/ml), and 67 strains of Candida (MICs = 3.13 to >100 μg/ml).1 It acts by inhibiting squalene epoxidase.2 Butenafine (50 μM) inhibits the synthesis of ergosterol , a sterol in the cell membranes of fungi. Formulations containing butenafine have been used in the treatment of tinea pedis, tinea corporis, and tinea cruris.1.Maeda, T., Takase, M., Ishibashi, A., et al.Synthesis and antifungal activity of butenafine hydrochloride (KP-363), a new benzylamine antifungal agentYakugaku Zasshi111(2)126-137(1991)
2.Hiratani, T., Asagi, Y., and Yamaguchi, H.Studies on antifungal mechanism of action of butenafine hydrochloride. II. Comparison in the response to drug treatment between a wild-type strain and tolciclate-resistant mutant strains of Sporothrix schenckiiNihon Ishinkin Gakkai Zasshi32(2)139-149(1991)
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