產品屬性：
產品名稱 | Antisauvagine-30 TFA |
規格 | 1mg、5mg |
貨號 | EY-01Y16308 |
Cas No.: N/A
別名: N/A
化學名: N/A
分子式: C163H275N48F3O49S
分子量: 3764.28
溶解度: Soluble in DMSO
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Antisauvagine-30 TFA (aSvg-30 TFA) is a potent, highly selective and competitive CRF2 receptor peptidic antagonist. Antisauvagine-30 TFA exhibits a Kd of 1.4 nM and 150 nM for mCRFR2β and CRFR1, respectively[1][2][3][4].Antisauvagine-30 (aSvg-30) prevents stress-enhanced fear conditioning and Mek-1/2-dependent activation of Erk-1/2 and p90Rsk-1. Antisauvagine-30 (aSvg-30) did not affect the phosphorylation of the PKA regulatory subunit II of stressed mice[1][2].Antisauvagine-30 (aSvg-30; i.h. 400 ng/0.5 μl per mouse) selectively prevents the stress-induced enhancement of fear conditioning without affecting the fear conditioning of nonstressed mice[2].Antisauvagine-30 (aSvg-30) injected i.c.v. elicits a significant anxiogenic effect[3].
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