產品屬性：
產品名稱 | Colupulone |
規格 | 1 mg、5 mg |
貨號 | EY-01Y16391 |
Cas No.: 468-27-9
別名: N/A
化學名: N/A
分子式: C25H36O4
分子量: 400.6
溶解度: DMSO: soluble,Methanol: soluble
儲存條件: -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Colupulone is a β-acid that has been found in H. lupulus and has diverse biological activities.1,2,3 It activates the pregnane X receptor (PXR) in a reporter assay when used at concentrations of 1, 3, and 10 μM.1 Dietary administration of colupulone (0.18% w/w) induces hepatic cytochrome P450 (CYP) isoform 3A (CYP3A) activity in mice.2 It also decreases serum glucose levels in non-diabetic mice and increases serum glucose levels in db/db mice.31.Teotico, D.G., Bischof, J.J., Peng, L., et al.Structural basis of human pregnane X receptor activation by the hops constituent colupuloneMol. Pharmacol.74(6)1512-1520(2008)
2.Mannering, G.J., Shoeman, J.A., and Deloria, L.B.Identification of the antibiotic hops component, colupulone, as an inducer of hepatic cytochrome P-4503A in the mouseDrug Metab. Dispos.20(2)142-147(1992)
3.Mannering, G.J., Shoeman, J.A., and Shoeman, D.W.Effects of colupulone, a component of hops and brewers yeast, and chromium on glucose tolerance and hepatic cytochrome P450 in nondiabetic and spontaneously diabetic miceBiochem. Biophys. Res. Commun.200(3)1455-1462(1994)
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