產品屬性：
產品名稱 | Cobaltic Protoporphyrin IX (chloride) |
規格 | 10 mg、25 mg、50 mg、100 mg |
貨號 | EY-01Y16380 |
Cas No.: 102601-60-5
別名: N/A
化學名: N/A
分子式: C34H30ClCoN4O4·2H
分子量: 655
溶解度: DMF: 30 mg/ml,DMF:PBS (pH 7.2) (1:6): 0.14 mg/ml,DMSO: 25 mg/ml,Ethanol: 1 mg/ml
儲存條件: -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Cobaltic protoporphyrin IX is a metalloporphyrin and an inducer of heme oxygenase-1 (HO-1) activity.1 Unlike other metalloporphyrins, cobaltic protoporphyrin IX induces activity of HO-1, the rate-limiting enzyme in heme catabolism, in vitro and in vivo.1,2 It also reduces the activity of δ-aminolevulinate synthase, the enzyme that catalyzes the rate-limiting step of heme biosynthesis, as well as decreases the activity of cytochrome P450 (CYP), in rat liver microsomes ex vivo when administered at a dose of 125 μmol/kg.2 Cobaltic protoporphyrin IX (5 mg/kg) prevents liver injury and increases in the percentage of hepatic apoptotic cells in a mouse model of liver ischemia-reperfusion injury.3 It increases survival and decreases the number of lung colony forming units (CFUs) in mice infected with Y. pestis at the same dose.4 Cobaltic protoporphyrin IX has also been used as a catalyst for the electrochemical reduction of carbon dioxide in carbon electrodes.5 1.Shan, Y., Lambrecht, R.W., Donohue, S.E., et al.Role of Bach1 and Nrf2 in up-regulation of the heme oxygenase-1 gene by cobalt protoporphyrinFASEB J.20(14)2651-2653(2006)
2.Drummond, G.S., and Kappas, A.The cytochrome P-450-depleted animal: An experimental model for in vivo studies in chemical biologyProc. Natl. Acad. Sci. USA79(7)2384-2388(1982)
3.Li, J., Wu, B., Teng, D., et al.Cobalt-protoporphyrin enhances heme oxygenase 1 expression and attenuates liver ischemia/reperfusion injury by inhibiting apoptosisMol. Med. Rep.17(3)4567-4572(2018)
4.Willix, J.L., Stockton, J.L., Olson, R.M., et al.Activation of heme oxygenase expression by cobalt protoporphyrin treatment prevents pneumonic plague caused by inhalation of Yersinia pestisAntimicrob. Agents Chemother.64(4)e01819-01819(2020)
5.Shen, J., Kortlever, R., Kas, R., et al.Electrocatalytic reduction of carbon dioxide to carbon monoxide and methane at an immobilized cobalt protoporphyrinNat. Commun.68177(2015)
特別提醒公司產品僅供科研使用
