產品屬性：
產品名稱 | Atuliflapon |
規格 | 10mM*1 mL in DMSO、5 mg、10 mg、25 mg |
貨號 | EY-01Y16429 |
Cas No.: 2041075-86-7
別名: N/A
化學名: N/A
分子式: C24H26N6O3
分子量: 446.5
溶解度: DMSO : 125 mg/mL (279.96 mM; Need ultrasonic)
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
AZD5718 is an orally active inhibitor of FLAP (5?Lipoxygenase activating protein), with an IC50 of 2 nM. AZD5718 is used in the study for coronary artery disease[1].AZD5718 demonstrates a dose dependent and greater than 90% suppression of leukotriene production over 24 h[1].AZD5718 exhibits an IC50 of 39 nM for LTB4[1].AZD5718 exhibits t1/2 of 0.45 h and 2.1 h in rat and dog by iv injection, respectively[1].[1]. Daniel Pettersen, et al. Discovery and Early Clinical Development of an Inhibitor of 5-Lipoxygenase Activating Protein (AZD5718) for Treatment of Coronary Artery Disease. J Med Chem. 2019 May 9;62(9):4312-4324.
特別提醒公司產品僅供科研使用
