產品屬性：
產品名稱 | AZD2423 |
規格 | 5mg、10mg |
貨號 | EY-01Y16659 |
Cas No.: 1229603-37-5
別名: N/A
化學名: N/A
分子式: C20H29ClFN5O2
分子量: 425.93
溶解度: DMSO: 200 mg/mL (469.56 mM)
儲存條件: 4°C, stored under nitroge
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
AZD2423 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator. AZD2423 has an IC50 of 1.2 nM for CCR2 Ca2+ flux [1][2][3].AZD2423 inhibits MCP-1 induced calcium mobilization and chemotaxis of THP-1 cell line with an IC50 of 4 nM[1].[1]. AZD2423.
[2]. John G. Cumming. CCR2 antagonists for the treatment of neuropathic pain: The discovery and development of AZD2423.
[3]. Kalliom?ki J, et al. A randomized, double-blind, placebo-controlled trial of a chemokine receptor 2 (CCR2) antagonist in posttraumatic neuralgia. Pain. 2013 May;154(5):761-7.
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